Gel-One Injections

What is Gel-One?

Gel-One Hyaluronate by Zimmer-Biomet is an injectable hyaluronate gel approved for the treatment of osteoarthritis (OA) of the knee that does not respond to other conservative treatments. It is the first low-volume viscosupplement available in a single-injection formula. Unlike other viscosupplement treatments, highly purified Gel-One Hyaluronate requires only 3mL for safe, effective and complete treatment with no reports of pseudo-sepsis (severe acute inflammatory responses) in the pre-market clinical study.

Who should receive Gel-One?

This treatment is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to non-pharmacologic therapy, non-steroidal anti-inflammatory drugs (NSAIDs) or simple analgesics like acetaminophen.

Who should not receive Gel-One?

Those who are allergic to hyaluronan products, cinnamon, or products from birds such as feathers, eggs, and poultry should not receive Gel-One Hyaluronate and should speak to their orthopedic surgery team about these allergies. Gel-One injections should not be given in areas of a skin disease or infection. 

Gel-One Hyaluronate has not been tested to show pain relief in joints other than the knee and for conditions other than OA. Gel-One Hyaluronate has not been tested in patients who are pregnant, mothers who are nursing, or anyone under the age of 21. Strenuous or prolonged weight-bearing activities after treatment are not recommended. The effectiveness of repeat treatment cycles of Gel-One Hyaluronate has not been established. The side effects most commonly seen after injection of Gel-One Hyaluronate in the clinical trial were knee pain, swelling, and/or knee effusion. These reactions are generally mild and do not last long.

Not all insurance companies cover the cost of Gel-One Injections, consult your healthcare provider for insurance requirements and coverage.  It is common to require pre-certification from your insurance company to ensure the injection from your provider is covered.  If you are interested in getting a Gel-One injection, please let you healthcare provider know when setting your appointment to allow for time to get this prior approval.

We are here to help. If you believe you are suffering from one of these conditions, we would love to deliver a diagnosis, get you treated and get you moving again.

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